ADP‐heptose enables <i>Helicobacter pylori</i> to exploit macrophages as a survival niche by suppressing antigen‐presenting HLA‐II expression
نویسندگان
چکیده
The persistence of Helicobacter pylori in the human gastric mucosa implies that immune response fails to clear infection. We found H. compromises antigen presentation ability macrophages, because decline presenting molecules HLA-II. Here, we reveal main bacterial factor responsible for this effect is ADP-heptose, an intermediate metabolite biosynthetic pathway lipopolysaccharide (LPS) elicits a pro-inflammatory epithelial cells. In it upregulates expression miR146b which, turn, would downmodulate CIITA, master regulator HLA-II genes. Hence, pylori, utilizing exploits specific arm macrophage establish its survival niche face defense elicited mucosa.
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2021
ISSN: ['0014-5793', '1873-3468']
DOI: https://doi.org/10.1002/1873-3468.14156